Last year I was plagued with an issues on many SharePoint Servers I work on, in which when I expanded IIS I received a message that The path specified cannot be used at this time. I even blogged a workaround for this error.
Well, after working with PSS for a number of months they released a hotfix for me. I applied it a number of months ago and since then haven’t seen the error. I just found out that this hotfix is now publicly accessible. If you are receiving this error check out the KB article and hotfix. It may save you a ton of headache.